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PROW: CD105
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PROW and IWHLDA present the GUIDE on:
CD105
Author: Michelle Letarte
Reviewer: Carmelo Bernabeu
[GUIDE BAR]

ALTERNATE NAMES FOR CD105  

MAJOR LINKS FOR CD105  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD105  

CELLULAR FUNCTION OF CD105  

DISEASE RELEVANCE OF CD105 AND FUNCTION OF CD105 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD105  

MOLECULAR STRUCTURE OF CD105  

MOLECULAR MASS OF CD105  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
HUVEC 180 90  
Endoglin transfectants 180 90  
Macrophages 180 90  
Pre-B leukemia 180 90  

POST-TRANSCRIPTIONAL MODIFICATION OF CD105  

POST-TRANSLATIONAL MODIFICATION OF CD105  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD105   - No information

SUBSTRATES FOR CD105   - No information

ENZYMES WHICH MODIFY CD105   - No information

LIGANDS FOR CD105 AND MOLECULES ASSOCIATED WITH CD105  

MOLECULECOMMENT
TGF-beta 1 Bound by CD105 in association with TGF-beta receptor II and I, both serine kinases
TGF-beta 3 Bound by CD105 in association with TGF-beta receptor II and I, both serine kinases

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD105  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD105   - No information


REAGENTS
CD105-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CLE4 Shant Kumar, Manchester, England  
K22-2H7 Andrew Boyd & Mathias Zaiss, Victoria, Australia  
43A3 Hans-Jorg Bühring, Tubingen, Germany  
Immu-40.19 Joelle Hirn, Marseille, France  
TEA3/17 Francisco Sanchez-Madrid, Madrid, Spain  
29-G8 Oskar Rokhlin, Iowa City , USA  
SN6 Ben, K. Seon, Buffalo, USA  
SN6h Ben, K. Seon, Buffalo, USA  

SELECTION OF OTHER CD105-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
44G4 [1]  
1G2 [1]  
E-9 [1]  
GRE [1]  
MAEND 3    
8E11    
RMAC-8    
PN-E2    
CLB-HEC-19    
F430C-5    

 
SELECTED REFERENCES ON CD105  

REVIEWS

1. Letarte M, Greaves A, and Vera S (1995). In: Leukocyte Typing V (ed. Schlossman SF et al) Oxford University Press, Oxford. 1756-1759.

PRIMARY CITATIONS

2. Bellon T,Corbi A,Lastres P,Cales C,Cebrian M,Vera S,Cheifetz S,Massague J,Letarte M,Bernabeu C Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur J Immunol 1993 23:2340 PubMed

3. Cheifetz S,Bellon T,Cales C,Vera S,Bernabeu C,Massague J,Letarte M Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem 1992 267:19027 PubMed

4. Gougos A,Letarte M Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line. J Immunol 1988 141:1925 PubMed

5. Gougos A,Letarte M Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J Biol Chem 1990 265:8361 PubMed

6. Lastres P,Letamendia A,Zhang H,Rius C,Almendro N,Raab U,Lopez LA,Langa C,Fabra A,Letarte M,Bernabeu C Endoglin modulates cellular responses to TGF-beta 1. J Cell Biol 1996 133:1109 PubMed

7. Lastres P,Martin-Perez J,Langa C,Bernabeu C Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin. Biochem J 1994 301:765 PubMed

8. McAllister KA,Grogg KM,Johnson DW,Gallione CJ,Baldwin MA,Jackson CE,Helmbold EA,Markel DS,McKinnon WC,Murrell J,et al Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 1994 8:345 PubMed

9. Quackenbush EJ,Letarte M Identification of several cell surface proteins of non-T, non-B acute lymphoblastic leukemia by using monoclonal antibodies. J Immunol 1985 134:1276 PubMed

10. Rokhlin OW,Cohen MB,Kubagawa H,Letarte M,Cooper MD Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow. J Immunol 1995 154:4456 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov