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PROW: CD95
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CD95 FORUM
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DISEASE RELEVANCE / FUNCTION IN INTACT  From: Soorya Narayana     Date: 11/23/99
Subject: CD95 mutations predispose to systemic autoimmunity

CD95 mutations are associated with loss of regulation of B lymphocytes, which predisposes to systemic autoimmunity including systemic lupus erythematosus (SLE)

Vaishnaw AK, Elkon KB, Toubi E, Ohsako S, Drappa J, Buys S, Estrada J, Sitarz A, Zemel L and Chu JL. 1999. The spectrum of apoptotic defects and clinical manifestations, including systemic lupus erythematosus, in humans with CD95 (Fas/APO-1) mutations. Arthritis Rheum 42:1833-1842 PubMed



Modified 12/08/99   mpr@mail.nih.gov