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PROW: CD158a
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PROW and IWHLDA present the GUIDE on:
CD158a
Authors: R. Biassoni; Christina Bottino
Reviewer: Miguel Lopez-Botet
[GUIDE BAR]

ALTERNATE NAMES FOR CD158a  

MAJOR LINKS FOR CD158a  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD158a   - No information

CELLULAR FUNCTION OF CD158a  

DISEASE RELEVANCE OF CD158a AND FUNCTION OF CD158a IN INTACT ANIMAL   - No information


STRUCTURE
MOLECULAR FAMILY FOR CD158a  

MOLECULAR STRUCTURE OF CD158a  

MOLECULAR MASS OF CD158a  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
NK cells 58 kDa 58 kDa 42 kDa backbone [Inhibiting form (p58.1)]
NK cells 50 kDa 50 kDa 36 kDa cackbone [Activating form (p50.1)]

POST-TRANSCRIPTIONAL MODIFICATION OF CD158a   - No information

POST-TRANSLATIONAL MODIFICATION OF CD158a  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD158a   - No information

SUBSTRATES FOR CD158a   - No information

ENZYMES WHICH MODIFY CD158a   - No information

LIGANDS FOR CD158a AND MOLECULES ASSOCIATED WITH CD158a  

MOLECULECOMMENT
HLA-Cw4 and related alleles (HLA-Cw2, -Cw5 and -Cw6) and related allotypes displaying Asn 77 and Lys 80. Ligand
SHP-1 Tyrosine phosphatase SHP-1 binds to tyrosine phosphorylated ITIM in the cytoplasmic tail**

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD158a  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD158a  
REAGENTS
CD158a-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
EB6 A Van Aghtoven, Marseille  
HP-3E4 M Lopez-Botet, Madrid Note HP-3E4 mAb reacts with other members of the family (i.e. p50.3)

SELECTION OF OTHER CD158a-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CD158a  

REVIEWS

1. Moretta A,Bottino C,Vitale M,Pende D,Biassoni R,Mingari MC,Moretta L Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 1996 14:619 PubMed

2. NK cells, MHC class I antigens and missing self. Immunological Reviews, Vol.155,pp. 5-221 1997

PRIMARY CITATIONS

1. Moretta A,Bottino C,Pende D,Tripodi G,Tambussi G,Viale O,Orengo A,Barbaresi M,Merli A,Ciccone E,et al Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J Exp Med 1990 172:1589 PubMed

2. Melero I,Salmeron A,Balboa MA,Aramburu J,Lopez-Botet M Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes. J Immunol 1994 152:1662 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov