PROW: CD85

PROW and IWHLDA present the GUIDE on:
CD85
Authors: Karen A. Pulford; Margaret Jones; Gerhard Moldenhauer; Heddy Zola; David Y. Mason
Reviewer: Thomas F. Tedder
[GUIDE BAR]

ALTERNATE NAMES FOR CD85

MAJOR LINKS FOR CD85

No information

FUNCTION BIOCHEMICAL ACTIVITY OF CD85 - Unknown

CELLULAR FUNCTION OF CD85

Evidence that CD85 may play a role in T cell activation in peripheral blood

DISEASE RELEVANCE OF CD85 AND FUNCTION OF CD85 IN INTACT ANIMAL

Of diagnostic value for hairy cell leukemia and plasma cell neoplasms

STRUCTURE MOLECULAR FAMILY FOR CD85

MOLECULAR STRUCTURE OF CD85 - Unknown

MOLECULAR MASS OF CD85

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
Namalwa B cell line	110 kDa
Hairy cell leukemia	110 kDa

POST-TRANSCRIPTIONAL MODIFICATION OF CD85 - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD85 - N-glycosylated glycoprotein

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85 - Unknown

SUBSTRATES FOR CD85 - Unknown

ENZYMES WHICH MODIFY CD85 - Unknown

LIGANDS FOR CD85 AND MOLECULES ASSOCIATED WITH CD85 - Unknown

EXPRESSION MAIN CELLULAR EXPRESSION OF CD85

Expressed at high levels on plasma cells and at lower levels on mantle zone B cells and germinal center cells
Expressed at high levels on hairy cell leukemia
Expressed at very low levels on a few tissue macrophages
Present on CD19-positive B cells, 10% CD3-positive T cells (some individuals) and a subpopulation of NK cells in peripheral blood
Expression increased after PHA stimulation

AUTHOR'S ADDITIONAL INSIGHTS ON CD85 - No information

REAGENTS CD85-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
H47 (NL-152)	Hirohashi, et al. 1993

SELECTION OF OTHER CD85-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
VMP55 (CD85.1)	Pulford et al. 1991
GHI/75 (CD85.2)	Pulford et al. 1991

SELECTED REFERENCES ON CD85

REVIEWS

PRIMARY CITATIONS

1. Engel, P., Wagner, R., and Tedder, T.F. 1995. In Leucocyte typing V (ed. S.F. Schlossman et al.,), pp. 701-702. Oxford University Press, Oxford (1995).

2. Hirohashi N,Nakao M,Kubo K,Yamada A,Shichijo S,Hara A,Sagawa K,Itoh K A novel antigen (H47 Ag) on human lymphocytes involved in T cell activation. Cell Immunol 1993 152:371 PubMed

3. Moldenhauer, G., Schwarz-Albeiz, R., and Moller, P. 1995. In Leucocyte typing V (ed. S.F. Schlossman et al.,), pp. 623-636. Oxford University Press, Oxford.

4. Pulford K,Micklem K,Thomas J,Jones M,Mason DY A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms. Clin Exp Immunol 1991 85:429 PubMed

5. Pulford, K., Micklem, K.J., Thomas, J., Jones, M., Law, S.K., Willis, A.C. et al., 1995 In Leucocyte typing V (ed. S.F. Schlossman et al.,), pp. 702-703. Oxford University Press, Oxford.

6. Wagner, N., Engel, P., and Tedder, T.F. 1995. In Leucocyte typing V (ed. S.F. Schlossman et al.,), pp. 636-642. Oxford University Press, Oxford.

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov