• BA-1
• heat stable antigen, HSA

MAJOR LINKS FOR CD24  

• NCBI LocusLink Record: 934
• Mendelian Inheritance in Man (OMIM): 600074
• SwissProt annotated protein record: P25063

• Cross-linking of CD24 can induce increased intracellular Ca+2 in mature B lymphocytes (Fischer GF et al. 1990)

CELLULAR FUNCTION OF CD24  

• Unknown for human CD24
• Cross-linking of murine CD24 on early murine B cells can trigger apoptosis (Chappel MS et al. 1996)
• Murine CD24 may serve as a co-stimulatory molecule for CD4+ T cells (Liu Y et al. 1992); and affect B cell adhesion directly as an adhesion molecule or by modifying the specificity and/or avidity of other adhesive interactions such between VLA-4-VCAM-1 or VLA-4-fibronectin (Hahne M et al. 1994)

DISEASE RELEVANCE OF CD24 AND FUNCTION OF CD24 IN INTACT ANIMAL  

• Marker in staging B cell development. Expressed at high levels in small cell lung carcinoma (Jackson D et al. 1992)
• P-selectin ligand on human carcinomas involved in carcinoma binding to platelets (Aigner S et al 1997)**

• Families in which CD24 is a member
  • CD24-->CD24/HSA/CD52

MOLECULAR STRUCTURE OF CD24  

• Glycosylphosphatidylinositol anchored glycoprotein
• About 31-35 amino acids in mature protein after displacement of tail by GPI linkage (Kay R et al. 1991)

MOLECULAR MASS OF CD24  

POST-TRANSCRIPTIONAL MODIFICATION OF CD24   - None known

POST-TRANSLATIONAL MODIFICATION OF CD24  

• Displacement of C terminal 19-23 amino acids by GPI linkage
• Extensive N-linked glycosylation (Kay R et al. 1991)
• Extensive O-linked glycosylation (Kay R et al. 1991)

SUBSTRATES FOR CD24   - No information

ENZYMES WHICH MODIFY CD24   - No information

LIGANDS FOR CD24 AND MOLECULES ASSOCIATED WITH CD24 Link to additional info in FORUM  

• Homotypic binding reported for murine CD24

• Expressed throughout B cell development with extinction on plasma cells (Hardy RR et al. 1991)
• Expressed on mature granulocytes
• Expressed on a variety of epithelial cell types

• Recent studies in the murine model provide intriguing evidence of a role for murine CD24 in early lymphoid development (Hough MR et al. 1995, Hough MR et al. 1994) and provide further impetus to determine whether CD24 shares parallel functions in human B lymphocyte biology

SELECTION OF OTHER CD24-SPECIFIC REFERENCE MAB  

REVIEWS

PRIMARY CITATIONS

1. Aigner S, Sthoeger ZM, Fogel M, Weber E, Zarn J, Ruppert M, Zeller Y, Vestweber D, Stahel R, Sammar M and Altevogt P. CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells. Blood 1997 89:3385 ** PubMed

2. Bruce J, Symington FW, McKearn TJ and Sprent J. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 1981 127:2496 PubMed

3. Chappel MS, Hough MR, Mittel A, Takei F, Kay R and Humphries RK. Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J. Exp. Med. 1996 184:1638 PubMed

4. Fischer GF, Majdic O, Gadd S and Knapp W. Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules. J. Immunol. 1990 144:638 PubMed

5. Hahne M, Wenger RH, Vestweber D and Nielsen PJ. The heat-stable antigen can alter very late antigen 4-mediated adhesion. J. Exp. Med. 1994 179:1391 PubMed

6. Hardy RR, Carmack CE, Shinton SA, Kemp JD and Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 1991 173:1213 PubMed

7. Hough MR, Chappel MS, Sauvageau G, Takei F, Kay R and Humphries RK. Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen. J. Immunol. 1996 156:479 PubMed

8. Hough MR, Takei F, Humphries RK and Kay R. Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen. J. Exp. Med. 1994 179:177 PubMed

9. Jackson D, Waibel R, Weber E, Bell J and Stahel RA. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. Cancer Res. 1992 52:5264 PubMed

10. Kadmon G, Eckert M, Sammar M, Schachner M and Altevogt P. Nectadrin, the heat-stable antigen, is a cell adhesion molecule. J. Cell Biol. 1992 118:1245 PubMed

11. Kay R, Rosten PM and Humphries RK. CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. J. Immunol. 1991 147:1412 PubMed

12. Liu Y, Jones B, Aruffo A, Sullivan KM, Linsley PS and Janeway CA Jr. Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J. Exp. Med. 1992 175:437 PubMed

13. Sammar M, Aigner S, Hubbe M, Schirrmacher V, Schachner M, Vestweber D and Altevogt P. Heat-stable antigen (CD24) as ligand for mouse P-selectin. Int. Immunol. 1994 6:1027 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov