• From: Mark Paalman     Date: 08/21/97
  Subject: CD24 as a ligand for P-selectin on human tumor cells

  CD24 is reported to be a ligand for P-selectin on human tumor cells.

  Aigner S, Sthoeger ZM, Fogel M, Weber E, Zarn J, Ruppert M, Zeller Y, Vestweber D, Stahel R, Sammar M and Altevogt P. CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells. Blood 1997 89:3385 PubMed
  
  

• From: Mark Shlomchik     Date: 08/10/97
  Subject: Low CD24 expression on memory B cells

  CD24lo on memory B cells may represent a separate lineage of B cells. While this issue is quite controversial, the point that memory B cells in mice are low in CD24 has been replicated by several laboratories. Decker et al. and Linton et al. make controversial assignments of CD24lo to a memory lineage. Allman et al. show that CD24hi on splenic B cells mark an immature splenic subset.

  Bruce J, Symington FW, McKearn TJ and Sprent J. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 1981 127:2496 PubMed

  Pillai PS, Reynolds SD, Chace JH and Scott DW. Differential expression of a surface antigen recognized by a monoclonal antibody, J11d, on unprimed and primed B cells. J. Immunol. 1986 137:791 PubMed

  Decker DJ, Linton PJ, Zaharevitz S, Biery M, Gingeras TR and Klinman NR. Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro. Immunity 1995 2:195 PubMed

  Allman DM, Ferguson SE, Lentz VM and Cancro MP. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 1993 151:4431 PubMed

  Linton PJ L, Decker DJ and Klinman NR. Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations. Cell 1989 59:1049 PubMed
  
  

Modified 10/14/99   mpr@mail.nih.gov