PROW: CD83

PROW and IWHLDA present the GUIDE on:
CD83
Author: Thomas F. Tedder
Reviewer: Shinichi Sato
[GUIDE BAR]

ALTERNATE NAMES FOR CD83

HB15

MAJOR LINKS FOR CD83

NCBI LocusLink Record: 9308
SwissProt annotated protein record: Q01151

FUNCTION BIOCHEMICAL ACTIVITY OF CD83 - No information

CELLULAR FUNCTION OF CD83 - Unknown

DISEASE RELEVANCE OF CD83 AND FUNCTION OF CD83 IN INTACT ANIMAL - No information

STRUCTURE MOLECULAR FAMILY FOR CD83

Families in which CD83 is a member
- CD83-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD83

transmembrane protein
Single extracellular V-type Ig like domain
~40 amino acid cytoplasmic domain

MOLECULAR MASS OF CD83

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
cDNA-transfected K562 cells		43 kDa

POST-TRANSCRIPTIONAL MODIFICATION OF CD83 - No information

POST-TRANSLATIONAL MODIFICATION OF CD83 - Heavily glycosylated

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD83 - No information

SUBSTRATES FOR CD83 - No information

ENZYMES WHICH MODIFY CD83 - No information

LIGANDS FOR CD83 AND MOLECULES ASSOCIATED WITH CD83 - No information

EXPRESSION MAIN CELLULAR EXPRESSION OF CD83

Non-follicular dendritic cells
Circulating dendritic cells
Interdigitating dendritic cells within lymphoid tissues
Langerhan's cells
In vitro generated dendritic cells
Thymic dendritic cells
Weak reactivity with some lymphoblastoid cell lines and with some germinal center B cells in vivo

AUTHOR'S ADDITIONAL INSIGHTS ON CD83

Currently one of the bast markers for human mature dendritic cells

REAGENTS CD83-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP - None

SELECTION OF OTHER CD83-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
HB15a	TF Tedder, Durham
HB15b	TF Tedder, Durham

SELECTED REFERENCES ON CD83

REVIEWS

PRIMARY CITATIONS

1. Egner W,Hart DN The phenotype of freshly isolated and cultured human bone marrow allostimulatory cells: possible heterogeneity in bone marrow dendritic cell populations. Immunology 1995 85:611 PubMed

2. Engel, P., Wagner, N. and Tedder, T.F. in Leukocyte Typing V. White Cell Differentiation Antigens (eds. Schlossman, S.F.) 693 (Oxford University Press, Oxford, 1995).

3. Fanger NA,Wardwell K,Shen L,Tedder TF,Guyre PM Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. J Immunol 1996 157:541 PubMed

4. Kozlow EJ,Wilson GL,Fox CH,Kehrl JH Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes. Blood 1993 81:454 PubMed

5. Weissman D,Li Y,Ananworanich J,Zhou LJ,Adelsberger J,Tedder TF,Baseler M,Fauci AS Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. Proc Natl Acad Sci U S A 1995 92:826 PubMed

6. Zhou LJ,Schwarting R,Smith HM,Tedder TF A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J Immunol 1992 149:735 PubMed

7. Zhou LJ,Tedder TF A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. Blood 1995 86:3295 PubMed

8. Zhou LJ,Tedder TF CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci U S A 1996 93:2588 PubMed

9. Zhou LJ,Tedder TF Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol 1995 154:3821 PubMed

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov