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PROW: CD68
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PROW and IWHLDA present the GUIDE on:
CD68
Author: Sanna M. Goyert
Reviewers: Walter Knapp; Herbert Strobl
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ALTERNATE NAMES FOR CD68  

MAJOR LINKS FOR CD68  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD68   - No information

CELLULAR FUNCTION OF CD68   - Unknown at this time

DISEASE RELEVANCE OF CD68 AND FUNCTION OF CD68 IN INTACT ANIMAL   - No information


STRUCTURE
MOLECULAR FAMILY FOR CD68  

MOLECULAR STRUCTURE OF CD68  

MOLECULAR MASS OF CD68  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Unspecified 110 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD68   - No information

POST-TRANSLATIONAL MODIFICATION OF CD68   - Highly glycosylated


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD68   - No information

SUBSTRATES FOR CD68   - No information

ENZYMES WHICH MODIFY CD68   - No information

LIGANDS FOR CD68 AND MOLECULES ASSOCIATED WITH CD68  

MOLECULECOMMENT
Oxidatively modified low density lipoprotein Bound by murine macrosialin

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD68  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD68   - No information


REAGENTS
CD68-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - No information

SELECTION OF OTHER CD68-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Y-1/82a (MR23) Davey et al. 1988  
Y2/131 (MR24) Pulford et al. 1989  

 
SELECTED REFERENCES ON CD68  

REVIEWS

PRIMARY CITATIONS

1. Cordell JL, Falini B, Flenghi L, Jones DB, Pileri S, Radzun HJ, and WilkinsBS. Leukocyte Typing V 925-927

2. Davey FR,Cordell JL,Erber WN,Pulford KA,Gatter KC,Mason DY Monoclonal antibody (Y1/82A) with specificity towards peripheral blood monocytes and tissue macrophages. J Clin Pathol 1988 41:753 PubMed

3. Fukuda M Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking. J Biol Chem 1991 266:21327 PubMed

4. Holness CL,Simmons DL Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 1993 81:1607 PubMed

5. Pulford KA,Rigney EM,Micklem KJ,Jones M,Stross WP,Gatter KC,Mason DY KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol 1989 42:414 PubMed

6. Pulford KA,Sipos A,Cordell JL,Stross WP,Mason DY Distribution of the CD68 macrophage/myeloid associated antigen. Int Immunol 1990 2:973 PubMed

7. Rabinowitz SS,Gordon S Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J Exp Med 1991 174:827 PubMed

8. Ramprasad MP,Fischer W,Witztum JL,Sambrano GR,Quehenberger O,Steinberg D The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68. Proc Natl Acad Sci U S A 1995 92:9580 ** PubMed

9. Ramprasad MP,Terpstra V,Kondratenko N,Quehenberger O,Steinberg D Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc Natl Acad Sci U S A 1996 93:14833 ** PubMed

10. Stockinger, H., Leukocyte Typing IV, (ed. W. Knapp et al.) pp. 841-843.Oxford University Press, Oxford (1989)

11. Strobl H,Scheinecker C,Csmarits B,Majdic O,Knapp W Flow cytometric analysis of intracellular CD68 molecule expression in normal and malignant haemopoiesis. Br J Haematol 1995 90:774 * PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov