PROW: CD18

PROW and IWHLDA present the GUIDE on:
CD18
Author: Nancy Hogg
Reviewer: Timothy A. Springer
[GUIDE BAR]

ALTERNATE NAMES FOR CD18

CD11a beta subunit
CD11b beta subunit
CD11c beta subunit
beta-2 integrin, beta2, beta 2
beta-2 integrin chain

MAJOR LINKS FOR CD18

NCBI LocusLink Record: 3689
Mendelian Inheritance in Man (OMIM): 116920
Mendelian Inheritance in Man (OMIM): 600065
SwissProt annotated protein record: P05107

FUNCTION BIOCHEMICAL ACTIVITY OF CD18 - No information

CELLULAR FUNCTION OF CD18

Adhesion and signaling in the hematopoietic system: see entries for CD11a, CD11b, and CD11c

DISEASE RELEVANCE OF CD18 AND FUNCTION OF CD18 IN INTACT ANIMAL

Leukocyte Adhesion Deficiency (LAD-1) caused by lesion in CD18 gene coding for common b2 subunit; patients suffer from recurrent infections
General importance in inflammatory responses tested in CD18 "knockout" mice (see Wilson et al., 1993)

STRUCTURE MOLECULAR FAMILY FOR CD18

Families in which CD18 is a member
- CD18-->integrin beta chains-->integrin assemblies

MOLECULAR STRUCTURE OF CD18

Type 1 transmembrane protein
747 amino acids (678 extracellular, 23 transmembrane, 46 cytoplasmic)

MOLECULAR MASS OF CD18

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
Leukocytes	90 kDa	95 kDa

POST-TRANSCRIPTIONAL MODIFICATION OF CD18 - No information

POST-TRANSLATIONAL MODIFICATION OF CD18 - No information

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD18 - No information

SUBSTRATES FOR CD18 - No information

ENZYMES WHICH MODIFY CD18 - No information

LIGANDS FOR CD18 AND MOLECULES ASSOCIATED WITH CD18

See entries for CD11a, CD11b, and CD11c

EXPRESSION MAIN CELLULAR EXPRESSION OF CD18 - Expressed by all leukocytes

AUTHOR'S ADDITIONAL INSIGHTS ON CD18 - No information

REAGENTS CD18-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
7E4	A van Agthoven
MEM-148	V Horejsi
AZN-L18	Y van Kooyk
AZN-L27	Y van Kooyk
BU86 (4F1)	DL Hardie
BU87	DL Hardie

SELECTION OF OTHER CD18-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
CLB-LFA-1	R van Lier
MHM-23	A McMichael
TS1/18	ATCC/TA Springer

SELECTED REFERENCES ON CD18

REVIEWS

1. Anderson DC,Springer TA Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 1987 38:175 PubMed

2. Springer TA Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994 76:301 PubMed

PRIMARY CITATIONS

3. Kishimoto TK,Hollander N,Roberts TM,Anderson DC,Springer TA Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell 1987 50:193 PubMed

4. Kishimoto TK,O'Connor K,Lee A,Roberts TM,Springer TA Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell 1987 48:681 PubMed

5. Law SK,Gagnon J,Hildreth JE,Wells CE,Willis AC,Wong AJ The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor. EMBO J 1987 6:915 PubMed

6. Weitzman JB,Wells CE,Wright AH,Clark PA,Law SK The gene organisation of the human beta 2 integrin subunit (CD18). FEBS Lett 1991 294:97 PubMed

7. Wilson RW,Ballantyne CM,Smith CW,Montgomery C,Bradley A,O'Brien WE,Beaudet AL Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol 1993 151:1571 PubMed

WWW RESOURCES

CD18 from NCBI Entrez

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov