• From: Scott Gray-Owen     Date: 10/06/97
  Subject: CD66e as receptor for N. gonorrhoeae

  The CD66 (CEA) family proteins (specifically CD66a, c, d, and e) have recently been reported to function as the receptors which the bacterial species Neisseria gonorrhoeae and Neisseria meningitidis use to mediate adherence to and cellular invasion of endothelia, epithelia and granulocytic cells (Virji et al. 1996; Chen and Gotschlich 1996; Gray-Owen et al. 1997). The differential specificity of distinct phase-variable Opa proteins expressed by these bacteria for individual CD66 members influences both tissue interactions and cellular response to bacterial binding via these receptors (Gray-Owen et al. 1997, in press).

  Virji M, Makepeace K, Ferguson DJ and Watt SM. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae. Mol. Microbiol. 1996 22:941 PubMed

  Chen T and Gotschlich EC. CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins. Proc. Natl. Acad. Sci. U.S.A. 1996 93:14851 PubMed

  Gray-Owen SD, Dehio C, Haude A, Grunert F and Meyer TF. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. EMBO J. 1997 16:3435 PubMed

  Gray-Owen SD, Lorenzen DR, Haude A, Meyer TF and Dehio C. Differential Opa sepcificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeae. Mol. Microbiol. 1997 26:in press
  
  

Modified 10/14/99   mpr@mail.nih.gov