• Pk blood group antigen
• burkitt's lymphoma antigen, BLA
• ceramide trihexoside, CTH
• globotriaosylceramide, Gb3

MAJOR LINKS FOR CD77  

• No information

CELLULAR FUNCTION OF CD77  

• Cross-linking of CD77 induces apoptosis of Burkitt's lymphoma cells

DISEASE RELEVANCE OF CD77 AND FUNCTION OF CD77 IN INTACT ANIMAL   - No information

• Families in which CD77 is a member
  • CD77-->carbohydrates with CD designation

MOLECULAR STRUCTURE OF CD77  

• Neutral glycosphingolipid: Gala1->4Galb1->4Glcb1->Ceramide

MOLECULAR MASS OF CD77   - Formula weight 1052 (1 kDa)

POST-TRANSCRIPTIONAL MODIFICATION OF CD77   - No information

POST-TRANSLATIONAL MODIFICATION OF CD77   - No information

SUBSTRATES FOR CD77   - No information

ENZYMES WHICH MODIFY CD77   - No information

LIGANDS FOR CD77 AND MOLECULES ASSOCIATED WITH CD77  

• Germinal center B lymphocytes
• Highly expressed on Burkitt's lymphoma cells and weakly expressed on some follicular center lymphomas

SELECTION OF OTHER CD77-SPECIFIC REFERENCE MAB  

REVIEWS

PRIMARY CITATIONS

1. Brodin NT,Dahmen J,Nilsson B,Messeter L,Martensson S,Heldrup J,Sjogren HO,Lundblad A Monoclonal antibodies produced by immunization with neoglycoproteins containing Gal alpha 1-4Gal beta 1-4Glc beta-O and Gal alpha 1-4Gal beta 1-4GlcNAc beta-O residues: useful immunochemical and cytochemical reagents for blood group P antigens and a differentiation marker in Burkitt lymphoma and other B-cell malignancies. Int J Cancer 1988 42:185 PubMed

2. Fyfe G,Cebra-Thomas JA,Mustain E,Davie JM,Alley CD,Nahm MH Subpopulations of B lymphocytes in germinal centers. J Immunol 1987 139:2187 PubMed

3. Gregory CD,Tursz T,Edwards CF,Tetaud C,Talbot M,Caillou B,Rickinson AB,Lipinski M Identification of a subset of normal B cells with a Burkitt's lymphoma J Immunol 1987 139:313 PubMed

4. Ito M,Suzuki E,Naiki M,Sendo F,Arai S Carbohydrates as antigenic determinants of tumor-associated antigens recognized by monoclonal anti-tumor antibodies produced in a syngeneic system. Int J Cancer 1984 34:689 PubMed

5. Maloney MD,Lingwood CA CD19 has a potential CD77 (globotriaosyl ceramide)-binding site with sequence similarity to verotoxin B-subunits: implications of molecular mimicry for B cell adhesion and enterohemorrhagic Escherichia coli pathogenesis. J Exp Med 1994 180:191 PubMed

6. Mangeney M,Lingwood CA,Taga S,Caillou B,Tursz T,Wiels J Apoptosis induced in Burkitt's lymphoma cells via Gb3/CD77, a glycolipid antigen. Cancer Res 1993 53:5314 PubMed

7. Mangeney M,Richard Y,Coulaud D,Tursz T,Wiels J CD77: an antigen of germinal center B cells entering apoptosis. Eur J Immunol 1991 21:1131 PubMed

8. Nudelman E,Kannagi R,Hakomori S,Parsons M,Lipinski M,Wiels J,Fellous M,Tursz T A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody. Science 1983 220:509 PubMed

9. O'Brien AD,Tesh VL,Donohue-Rolfe A,Jackson MP,Olsnes S,Sandvig K,Lindberg AA,Keusch GT Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Curr Top Microbiol Immunol 1992 180:65 PubMed

10. Oosterwijk E,Kalisiak A,Wakka JC,Scheinberg DA,Old LJ Monoclonal antibodies against Gal alpha 1-4Gal beta 1-4Glc (Pk, CD77) produced with a synthetic glycoconjugate as immunogen: reactivity with carbohydrates, with fresh frozen human tissues and hematopoietic tumors. Int J Cancer 1991 48:848 PubMed

11. Pascual V,Liu YJ,Magalski A,de Bouteiller O,Banchereau J,Capra JD Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 1994 180:329 PubMed

12. Thorbecke GJ,Amin AR,Tsiagbe VK Biology of germinal centers in lymphoid tissue. FASEB J 1994 8:832 PubMed

13. Wiels J,Fellous M,Tursz T Monoclonal antibody against a Burkitt lymphoma-associated antigen. Proc Natl Acad Sci U S A 1981 78:6485 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov