• intercellular adhesion molecule-1, ICAM-1

MAJOR LINKS FOR CD54  

• NCBI LocusLink Record: 3383
• Mendelian Inheritance in Man (OMIM): 147840
• SwissProt annotated protein record: P05362

CELLULAR FUNCTION OF CD54  

• React with CD11a / CD18 or CD11b / CD18 resulting in immune reaction and/or inflammation
• CD11a/CD18 positive cells such as neutrophils bind this molecule on the endothelial cells of the vessel
• Act as a receptor for Rhinovirus or RBCs infected with malarial parasite

DISEASE RELEVANCE OF CD54 AND FUNCTION OF CD54 IN INTACT ANIMAL  

• Some monoclonal antibodies to CD54 can reduce the reperfusion injury
• May be useful for preventing allograft rejection

• Families in which CD54 is a member
  • CD54-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD54  

• Type I transmembrane molecule (507 amino acids)
• Five constant regions C2 domains which belong to Ig superfamily*

MOLECULAR MASS OF CD54  

POST-TRANSCRIPTIONAL MODIFICATION OF CD54   - No information

POST-TRANSLATIONAL MODIFICATION OF CD54   - No information

• Many others are known**

SUBSTRATES FOR CD54   - No information

ENZYMES WHICH MODIFY CD54   - No information

LIGANDS FOR CD54 AND MOLECULES ASSOCIATED WITH CD54  

• Expressed, typically at high levels, an activated endothelial cells
• Expressed, at moderate levels, on activated T lymphocytes
• Expressed, at moderate levels, on activated B lymphocytes
• Expressed, at moderate levels, monocytes**
• ATL cells and some solid tumor cells express rather strongly this molecule *Inflammatory cytokines such as TNF, IL-1 and interferon gamma enhance the expression of CD54
• CD54 is inducible on epithelial, fibroblastic, and endothelial cells**
• CD54 is constitutively expressed in vivo on certain epithelia and endothelia**

• Soluble form of CD54 may act as an inhibitor of immune reaction between malignant cells and CTL or NK cells
• Soluble form or chimeric antibody could be used as therapeutic agent in autoimmune diseases

SELECTION OF OTHER CD54-SPECIFIC REFERENCE MAB  

REVIEWS

1. Springer TA Adhesion receptors of the immune system. Nature 1990 346:425 PubMed

2. Dustin ML,Staunton DE,Springer TA Supergene families meet in the immune system. Immunol Today 1988 9:213 PubMed

PRIMARY CITATIONS

3. Simmons D,Makgoba MW,Seed B ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 1988 331:624 PubMed

4. Caras IW,Davitz MA,Rhee L,Weddell G,Martin DW Jr,Nussenzweig V Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Nature 1987 325:545 PubMed

5. Medof ME,Lublin DM,Holers VM,Ayers DJ,Getty RR,Leykam JF,Atkinson JP,Tykocinski ML Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement. Proc Natl Acad Sci U S A 1987 84:2007 PubMed

6. Coyne KE,Hall SE,Thompson S,Arce MA,Kinoshita T,Fujita T,Anstee DJ,Rosse W,Lublin DM Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor. J Immunol 1992 149:2906 PubMed

7. Rothlein R,Dustin ML,Marlin SD,Springer TA A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986 137:1270 PubMed

8. Dustin ML,Rothlein R,Bhan AK,Dinarello CA,Springer TA Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986 137:245 PubMed

9. Tsujisaki M,Imai K,Hirata H,Hanzawa Y,Masuya J,Nakano T,Sugiyama T,Matsui M,Hinoda Y,Yachi A Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases. Clin Exp Immunol 1991 85:3 PubMed

10. Yamamura M,Hinoda Y,Sasaki S,Tsujisaki M,Oriuchi N,Endo K,Imai K A human/mouse chimeric monoclonal antibody against intercellular adhesion molecule-1 for tumor radioimmunoimaging. Jpn J Cancer Res 1996 87:405 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov