• B6
• BLAST-2
• FceRII
• Leu-20
• Low affinity IgE receptor

MAJOR LINKS FOR CD23  

• NCBI LocusLink Record: 2208
• Mendelian Inheritance in Man (OMIM): 151445
• SwissProt annotated protein record: P06734

CELLULAR FUNCTION OF CD23  

• Regulation of IgE synthesis
• Pro-inflammatory function: triggering of monokine release by human monocytes (i.e., TNF-, IL-1, IL-6, and GM-CSF)

DISEASE RELEVANCE OF CD23 AND FUNCTION OF CD23 IN INTACT ANIMAL  

• A Allergy:
• A1 Negative feedback regulation of IgE synthesis (CD23-/- mice have elevated serum IgE levels compared to WT mice). Some anti-CD23 antibodies decrease human IgE production
• A2 IgE-mediated Ag presentation is impaired in CD23-/- mice
• B Inflammation: Anti-CD23 mAb treatment decreased severity of collagen-induced arthritis
• C Chronic Lymphocytic Leukemia (CLL): Serum soluble CD23 level is a significant prognostic marker in CLL that discriminates, at the early stage of the disease, patients at high risk of disease progression

• Families in which CD23 is a member
  • CD23-->SiGLec-->sialoadhesin-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD23  

• Type II integral membrane glycoprotein

MOLECULAR MASS OF CD23  

POST-TRANSCRIPTIONAL MODIFICATION OF CD23  

• Alternate splicing of exon 2 generates two isoforms differing by 6 aa in the cytoplasmic region

POST-TRANSLATIONAL MODIFICATION OF CD23  

• CD23 proteolytic cleavage generates soluble CD23 fragments of various MW

SUBSTRATES FOR CD23   - No information

ENZYMES WHICH MODIFY CD23   - No information

LIGANDS FOR CD23 AND MOLECULES ASSOCIATED WITH CD23  

• Human cells: B, monocytes, FDC apical light zone (T, platelets, eosinophils, neutrophils, Langerhans cells)
• Rodent cells: B cells, FDC

• Major critical question is the confirmation of the existence of other ligands than IgE in rodents

SELECTION OF OTHER CD23-SPECIFIC REFERENCE MAB   - No information

REVIEWS

PRIMARY CITATIONS

1. Delespesse G,Sarfati M,Wu CY,Fournier S,Letellier M The low-affinity receptor for IgE. Immunol Rev 1992 125:77 PubMed

2. Lamers MC,Yu P Regulation of IgE synthesis. Lessons from the study of IgE transgenic and CD23-deficient mice. Immunol Rev 1995 148:71 PubMed

3. Ludin C,Hofstetter H,Sarfati M,Levy CA,Suter U,Alaimo D,Kilchherr E,Frost H,Delespesse G Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. EMBO J 1987 6:109 PubMed

4. Kikutani H,Inui S,Sato R,Barsumian EL,Owaki H,Yamasaki K,Kaisho T,Uchibayashi N,Hardy RR,Hirano T,et al Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell 1986 47:657 PubMed

5. Flores-Romo L,Shields J,Humbert Y,Graber P,Aubry JP,Gauchat JF,Ayala G,Allet B,Chavez M,Bazin H,et al Inhibition of an in vivo antigen-specific IgE response by antibodies to CD23. Science 1993 261:1038 PubMed

6. Aubry JP,Pochon S,Graber P,Jansen KU,Bonnefoy JY CD21 is a ligand for CD23 and regulates IgE production. Nature 1992 358:505 PubMed

7. Armant M,Ishihara H,Rubio M,Delespesse G,Sarfati M Regulation of cytokine production by soluble CD23: costimulation of interferon gamma secretion and triggering of tumor necrosis factor alpha release. J Exp Med 1994 180:1005 PubMed

8. Lecoanet-Henchoz S,Gauchat JF,Aubry JP,Graber P,Life P,Paul-Eugene N,Ferrua B,Corbi AL,Dugas B,Plater-Zyberk C,et al CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18. Immunity 1995 3:119 PubMed

9. Plater-Zyberk C,Bonnefoy JY Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo. Nat Med 1995 1:781 PubMed

10. Yu P,Kosco-Vilbois M,Richards M,Kohler G,Lamers MC Negative feedback regulation of IgE synthesis by murine CD23. Nature 1994 369:753 PubMed

11. Fujiwara H,Kikutani H,Suematsu S,Naka T,Yoshida K,Yoshida K,Tanaka T,Suemura M,Matsumoto N,Kojima S,et al The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A 1994 91:6835 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov