• Target for anti-proliferative antigen-1, TAPA-1

MAJOR LINKS FOR CD81  

• NCBI LocusLink Record: 975
• Mendelian Inheritance in Man (OMIM): 186845
• SwissProt annotated protein record: P18582

CELLULAR FUNCTION OF CD81  

• Member of CD19/CD21/Leu-13 signal transduction complex

DISEASE RELEVANCE OF CD81 AND FUNCTION OF CD81 IN INTACT ANIMAL   - Regulation of cell growth

• Families in which CD81 is a member
  • CD81-->TM4SF

MOLECULAR STRUCTURE OF CD81  

• Four transmembrane domains
• The NH2- and COOH- termini are both on the intracellular side of the membrane

MOLECULAR MASS OF CD81  

POST-TRANSCRIPTIONAL MODIFICATION OF CD81   - No information

POST-TRANSLATIONAL MODIFICATION OF CD81   - No information

SUBSTRATES FOR CD81   - No information

ENZYMES WHICH MODIFY CD81   - No information

LIGANDS FOR CD81 AND MOLECULES ASSOCIATED WITH CD81  

• Note 1 - CD19, CD21, Leu-13 and CD81 associate on B cell to make a signaling complex**

• Broadly expressed on hemopoietic cells
• Absent from erythrocytes and platelets and neutrophils
• Expressed by endothelial and epithelial cells

• Functions of this and other members of the tetraspan family are as yet poorly understood. It is hoped that at the next workshop studies will be carried out that will clarify their cellular function and relevance

SELECTION OF OTHER CD81-SPECIFIC REFERENCE MAB  

REVIEWS

PRIMARY CITATIONS

1. Andria ML,Hsieh CL,Oren R,Francke U,Levy S Genomic organization and chromosomal localization of the TAPA-1 gene. J Immunol 1991 147:1030 PubMed

2. Bradbury LE,Goldmacher VS,Tedder TF The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. J Immunol 1993 151:2915 PubMed

3. Bradbury LE,Kansas GS,Levy S,Evans RL,Tedder TF The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol 1992 149:2841 PubMed

4. Bradbury, L. and Tedder, T.F. In Leucocyte Typing V (ed S. Schlossman et al) 690-691 Oxford University Press, Oxford (1995).

5. Freedman, A., Phifer, J.S. and Svahn, J. In Leucocyte Typing V (ed S. Schlossman et al) p732-733 Oxford University Press, Oxford (1995)

6. Oren R,Takahashi S,Doss C,Levy R,Levy S TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol 1990 10:4007 PubMed

7. Schick MR,Nguyen VQ,Levy S Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels. J Immunol 1993 151:1918 PubMed

8. Takahashi S,Doss C,Levy S,Levy R TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol 1990 145:2207 PubMed

9. Tedder, T.F., Wagner, N. and Engel, P. in Leucocyte Typing V ed. Schlossman et al. (1996)

10. Vaickus L,Levy R Antiproliferative monoclonal antibodies: detection and initial characterization. J Immunol 1985 135:1987 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov