PROW: CD101

PROW and IWHLDA present the GUIDE on:
CD101
Author: Armand Bensussan
Reviewers: Michael B. Brenner; Gary J. Russell
[GUIDE BAR]

ALTERNATE NAMES FOR CD101

IGSF2 [HUGO gene name]
P126
V7
immunoglobulin superfamily, member 2

MAJOR LINKS FOR CD101

NCBI LocusLink Record: 9398

FUNCTION BIOCHEMICAL ACTIVITY OF CD101 - Unknown

CELLULAR FUNCTION OF CD101

Monoclonal antibodies against CD101 inhibit allogeneic T cell responses.
Mabs against CD101 costimulate T cell proliferation with suboptimal anti-CD3 activation*

DISEASE RELEVANCE OF CD101 AND FUNCTION OF CD101 IN INTACT ANIMAL - Unknown

STRUCTURE MOLECULAR FAMILY FOR CD101

Families in which CD101 is a member
- CD101-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD101

Predicted seven extracellular Ig-like domains which belong to the V-type category

MOLECULAR MASS OF CD101

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
Granulocytes	240	120
Activated T Lymphocytes	240	120

POST-TRANSCRIPTIONAL MODIFICATION OF CD101 - No information

POST-TRANSLATIONAL MODIFICATION OF CD101

Molecule is a glycoprotein with Asn-linked carbohydrates.
Predicted structure has seven potential Asn-linked sites*

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD101 - Unknown

SUBSTRATES FOR CD101 - Unknown

ENZYMES WHICH MODIFY CD101 - Unknown

LIGANDS FOR CD101 AND MOLECULES ASSOCIATED WITH CD101 - Unknown

EXPRESSION MAIN CELLULAR EXPRESSION OF CD101

Highly expressed on monocytes, granulocytes, dendritic cells and activated T lymphocytes

AUTHOR'S ADDITIONAL INSIGHTS ON CD101

The physiological function of CD101 is unknown

REAGENTS CD101-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
BC27	Bensussan Armand
V7.1	Engleman Edgar G, et al. 1995

SELECTION OF OTHER CD101-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
BB27	Bensussan Armand et al, 1994

SELECTED REFERENCES ON CD101

REVIEWS

PRIMARY CITATIONS

1. Gouttefangeas C, SchmidM , Boumsell L, and Bensussan A (1995). In Leukocyte Typing V, Vol 1, eds. Schlossman SF et al., Oxford University Press, 293-295.

2. Gouttefangeas C,Jacquot S,Meffre E,Schmid M,Boumsell L,Bensussan A Differential proliferative responses in subsets of human CD28+ cells delineated by BB27 mAb. Int Immunol 1994 6:423 PubMed

3. Ruegg CL,Rivas A,Madani ND,Zeitung J,Laus R,Engleman EG V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene. J Immunol 1995 154:4434 PubMed

4. Russell GJ,Parker CM,Sood A,Mizoguchi E,Ebert EC,Bhan AK,Brenner MB p126 (CDw101), a costimulatory molecule preferentially expressed on mucosal T lymphocytes. J Immunol 1996 157:3366 PubMed

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov