• SEMA4D [HUGO gene name]

MAJOR LINKS FOR CD100  

• NCBI LocusLink Record: 10507
• Mendelian Inheritance in Man (OMIM): 601866

• Associated with PTPase and serine kinase activity

CELLULAR FUNCTION OF CD100  

• Increases PMA, CD3 and CD2 induced T cell proliferation
• Increases CD45 induced T cell adhesion
• Induces B cell homotypic adhesion
• Down-regulates B cell expression of CD23

DISEASE RELEVANCE OF CD100 AND FUNCTION OF CD100 IN INTACT ANIMAL   - No information

• Families in which CD100 is a member
  • CD100-->semaphorin-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD100   - Homodimer

MOLECULAR MASS OF CD100  

POST-TRANSCRIPTIONAL MODIFICATION OF CD100   - No information

POST-TRANSLATIONAL MODIFICATION OF CD100   - No information

SUBSTRATES FOR CD100   - No information

ENZYMES WHICH MODIFY CD100   - No information

LIGANDS FOR CD100 AND MOLECULES ASSOCIATED WITH CD100  

• On most hematopoietic cells except immature bone marrow cells and K562 cell line except on RBC and platelets
• Increased expression after T cell activation
• Expressed on germinal center B cells but not mantle zone B cells

SELECTION OF OTHER CD100-SPECIFIC REFERENCE MAB  

REVIEWS

PRIMARY CITATIONS

1. Bougeret C,Mansur IG,Dastot H,Schmid M,Mahouy G,Bensussan A,Boumsell L Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation. J Immunol 1992 148:318 PubMed

2. Hall KT,Boumsell L,Schultze JL,Boussiotis VA,Dorfman DM,Cardoso AA,Bensussan A,Nadler LM,Freeman GJ Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A 1996 93:11780 PubMed

3. Herold C, Dastot H, Bensussan A, and Boumsell L (1995). In Leucocyte Typing V, Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder TF, and Todd RF eds. Oxford University Press, Oxford. 288-289.

4. Herold C, Dastot H, Bismuth G, Bensussan A, and Boumsell L (1995). In Leucocyte Typing V, Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder TF, and Todd RF eds. Oxford University Press, Oxford. 290-292.

5. Herold C, Elhabazi A, Bismuth G, Bensussan A, and Boumsell L. J Immunol in press.

6. Herold C,Bismuth G,Bensussan A,Boumsell L Activation signals are delivered through two distinct epitopes of CD100, a unique 150 kDa human lymphocyte surface structure previously defined by BB18 mAb. Int Immunol 1995 7:1 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov