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Star Republic: Guide for Biologists

IC/ED/GI/LD

IC50 inhibitory concentration 50% --- the concentration at which growth or activity is inhibited by 50%. Applies to ligand and growth inhibition.

ED or EC Effective dose (or concentration).

LD Lethal dose. LD50 --- the dose at which 50% of test subjects die.

GI50 growth inhibition 50% --- the drug concentration giving a 50% reduction int the net protein increase.

LC50 for drugs with cytotoxic effect, is the concentration of drug where 50% of cells die (a 50% reduction in the measured protein at the end of the drug treatment as compared to that at the begining).

TGI total growth inhibition.